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. 2022 Oct 20;13:991048. doi: 10.3389/fimmu.2022.991048

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Copyright © 2022 Yang, Le, Simovic, Liu, Fraker, Cancio, Cap, Wade, DalleLucca and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Early complement activation is detected in poly-trauma patients. The plasma samples were collected from patients on admission and at 3h, 6h, 12h, 24h, and 120h after admission, and the complement factors including Bb (A), C4d (B), C3a (C), C5a (D) and C5b-9 (E) were measured by ELISA. Healthy volunteers were also measured as a control. The numbers of analyzed patients for the individual groups are displayed in each column. The data were presented as mean ± SEM. T-test or Mann-Whitney U test was used to compare f differences between injured patients at the defined time point and the healthy control group. * p<0.05, ** p<0.01, *** p<0.001.