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. 2022 Oct 20;13:991048. doi: 10.3389/fimmu.2022.991048

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Copyright © 2022 Yang, Le, Simovic, Liu, Fraker, Cancio, Cap, Wade, DalleLucca and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Complement activation is associated with injury severity scores (ISS) in poly-trauma patients. The poly-trauma patients were divided into three groups ISS<16, ISS=16-24, and ISS>24, and complement factors Bb (A), C3a (B), C5a (C), and C5b-9 (D) in different categories were calculated, and the data were presented as mean ± SEM. The numbers of analyzed patients for the individual groups are displayed below the graph on each panel. Statistical analyses were performed by linear mixed-effect model for repeated measures and the least square means of each group comparison. *p<0.05, ISS>24 vs. ISS<16; †p<0.05, ISS>24 vs. ISS=16-24.