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. 2022 Oct 20;13:991048. doi: 10.3389/fimmu.2022.991048

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Copyright © 2022 Yang, Le, Simovic, Liu, Fraker, Cancio, Cap, Wade, DalleLucca and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Coagulation and fibrinolysis parameter abnormalities in poly-trauma patients. The blood samples were collected upon admission, and at 3h, 6h, 12h, 24h, and 120h after admission, and the coagulation and fibrinolysis parameters of factor I (A), factor V (B), D-dimer (C), sCD40L (D), ETP (E), peak (F), k-time (G), and LY30 (H) were measured by chromogenic assays, ELISA or TEG machines. The coagulation parameters in three different groups as ISS<16, ISS=16-24, and ISS>24 were calculated and the data were presented as mean ± SEM. The numbers of analyzed patients for the individual groups are displayed below the graph on each panel. Statistical analyses were performed by linear mixed-effect model for repeated measures and the least square means of each group comparison. * p<0.05, ISS>24 vs. ISS<16; † p<0.05, ISS>25 vs. ISS=16-24; # p<0.05, ISS=16-24 vs. ISS<16.