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. 2022 Oct 20;13:991048. doi: 10.3389/fimmu.2022.991048

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Copyright © 2022 Yang, Le, Simovic, Liu, Fraker, Cancio, Cap, Wade, DalleLucca and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Endothelial cell and tissue damage biomarkers lcorrelate with complement in severely injured patients. In severely injured patients (ISS>24), the endothelial cell and tissue damage biomarkers of syndecan-1 and hcDNA correlated with complement factors of C5a at admission (A, B). In addition, syndecan-1 also correlated to Bb (C), C3a (D), and C5b-9 (E) in severely injured patients (ISS>24) at admission. The correlation analyses were performed using Spearman’s rank correlation; the data were presented with a coefficient (r_s) and p values. Significant correlations (p <0.05) are indicated by boldface type.