Table 3.
Factors Associated with Odds of MOF/death and Infectious Complications.
| Univariate | MOF/death | Infectious Complications | ||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Gender, No. (%) | ||||
| Male vs. Female | 2.17 (0.46-10.16) | 0.327 | 2.20 (0.24-19.90) | 0.483 |
| Age at injury, each age increase | 1.01 (0.98-1.05) | 0.445 | 1.01 (0.97-1.04) | 0.742 |
| Race/Ethnicity | ||||
| Black vs. Caucasian | 0.52 (0.13-1.99) | 0.337 | n/a | n/a |
| Other vs. Caucasian | 0.87 (0.22-3.46) | 0.840 | 5.00 (1.13-22.05) | 0.034 |
| Other vs. Black | 1.68 (0.32-8.76) | 0.538 | n/a | n/a |
| ISS, each unit increase | 1.11 (1.04-1.18) | 0.002 | 1.09 (1.03-1.16) | 0.006 |
| Type of injury | ||||
| Blunt vs. penetrating | 3.54 (1.07-11.66) | 0.038 | 7.48 (0.88-63.44) | 0.065 |
| TBI, Yes vs. No | 3.21 (0.87-11.84) | 0.080 | 3.67 (0.95-14.15) | 0.059 |
| Complementopathy | ||||
| C3a | 1.00 (0.99-1.00) | 0.479 | 1.00 (0.99-1.00) | 0.233 |
| C5b-9 | 1.00 (0.99-1.00) | 0.567 | 1.00 (1.00-1.00) | 0.241 |
| Bb | 1.34 (0.78-2.31) | 0.289 | 1.44 (0.88-2.36) | 0.146 |
| Bb ≥1.57 vs. <1.57 | 3.75 (0.87-16.22) | 0.077 | 25.33 (2.61-245.73) | 0.005 |
| Endotheliopathy | ||||
| sTM | 1.30 (0.90-1.87) | 0.165 | 1.12 (0.74-1.68) | 0.604 |
| Syndecan-1 | 1.01 (1.00-1.03) | 0.034 | 1.01 (1.00-1.02) | 0.034 |
| Syndecan-1, ≥66.6 vs. <66.6 | 56.00 (5.58-561.75) | 0.001 | 5.60 (0.96-32.51) | 0.055 |
| Coagulopathy | ||||
| PT | 1.00 (0.98-1.03) | 0.799 | 1.01 (0.98-1.04) | 0.459 |
| PTT | 1.12 (0.98-1.29) | 0.088 | 1.01 (0.99-1.03) | 0.266 |
| LY30 | 1.03 (0.96-1.11) | 0.385 | 1.02 (0.98-1.07) | 0.316 |
| D-dimer | 1.22 (0.95-1.55) | 0.117 | 14.67 (1.73-124.20) | 0.014 |
| D-dimer, ≥6.0 vs. <6.0 | 10.31 (1.82-58.37) | 0.008 | 1.60 (0.34-7.46) | 0.549 |
| Triadic score*, each score increase | 7.39 (1.86-29.42) | 0.005 | 4.65 (1.41-15.30) | 0.012 |
| Adjusted models | ||||
| Triadic score, each score increase. Adjusted for ISS | 6.83 (1.04-44.96) | 0.046 | 4.12 (1.04-16.36) | 0.044 |
PT, prothrombin time; PTT, Partial thromboplastin time; LY30, percentage of clot lysis at 30 min after maximal clot strength;MOF, Multiple organ failure. *, Triadic score was caculated as a sum of scores of Bb (score=1 if Bb>1.57 µg/mL or=0 otherwise), syndecan-1 (score=1 if syndecan-1>66.6 ng/mL or=0 otherwise) and D-dimer (score=1 if D-dimer ≥6.0 or=0 otherwise). P-values were calculated using the logistic regression. n/a, not applicable. n/a, not applicable.