Table 1.
Clinical characteristics of general patients in the non-END and END groups.
| Non-END (n = 182) | END (n = 53) | P-value | |
|---|---|---|---|
| Age (years) | 65.96 ± 11.40 | 68.04 ± 10.64 | 0.222 |
| Male, N (%) | 122 (67.0%) | 34 (64.2%) | 0.696 |
| Onset to END time (days) | 4.00 (3.50–5.00) | ||
| Onset to NLR testing time (hours) | 50.00 (41.75–72.00) | 48.00 (42.00–67.00) | 0.484 |
| BMI (kg/m2) | 23.92 ±3.35 | 25.14 ±3.31 | 0.055 |
| Hypertension, N (%) | 151 (83.0%) | 45 (84.9%) | 0.738 |
| Diabetes, N (%) | 71 (39.0%) | 22 (41.5%) | 0.743 |
| Hyperlipidemia, N (%) | 52 (28.6%) | 9 (17.0%) | 0.090 |
| Coronary disease, N (%) | 16 (8.8%) | 1 (1.9%) | 0.088 |
| Previous stroke, N (%) | 39 (21.4%) | 11 (20.8%) | 0.916 |
| Smoking, N (%) | 83 (45.6%) | 22 (41.5%) | 0.598 |
| Drinking, N (%) | 50 (27.5%) | 14 (26.4%) | 0.879 |
| Initial NIHSS score | 3.00 (2.00–4.00) | 4.00 (3.00–5.00) | <0.001 |
| Type of SSI, N (%) | <0.001 | ||
| CSVD | 106 (58.2%) | 12 (22.6%) | |
| BAD | 76 (41.8%) | 41 (77.4%) | |
| Lesion location, N (%) | 0.714 | ||
| LSA | 89 (48.9%) | 23 (43.4%) | |
| AChA | 38 (20.9%) | 11 (20.8%) | |
| PPA | 55 (30.2%) | 19 (35.8%) | |
| Lesion diameter (mm) | 12.00 (9.00–17.00) | 17.00 (13.00–19.00) | <0.001 |
| Lesion depth (slide n) | 2.00 (1.00–3.00) | 2.00 (2.00–3.00) | 0.005 |
| FBG (mmol/L) | 5.44 (4.81–6.93) | 6.32 (4.90–8.59) | 0.083 |
| 2hPBG (mmol/L) | 7.80 (6.10–10.60) | 7.80 (6.30–12.00) | 0.399 |
| HbA1c (%) | 5.90 (5.50–7.14) | 5.97 (5.50–8.00) | 0.729 |
| TC (mmol/L) | 4.57 (3.90–5.54) | 4.53 (3.92–5.28) | 0.569 |
| TG (mmol/L) | 1.25 (1.01–1.96) | 1.18 (0.94–1.62) | 0.262 |
| HDL (mmol/L) | 1.03 (0.87–1.21) | 1.01 (0.87–1.18) | 0.672 |
| LDL (mmol/L) | 2.91 (2.31–3.39) | 2.71 (2.29–3.36) | 0.823 |
| Creatinine (umol/L) | 74.40 (60.10–87.15) | 70.75 (56.70–80.02) | 0.134 |
| eGFR (mL·min−1·1.73m−2) | 88.39 (73.83–98.33) | 87.25 (80.28–96.02) | 0.589 |
| White blood cells (× 109/L) | 6.59 (5.37–7.95) | 6.66 (5.32–8.50) | 0.694 |
| hs-CRP (mg/L) | 1.66 (0.94–3.84) | 2.40 (0.91–5.17) | 0.377 |
| NLR | 2.51 (1.82–3.36) | 3.01 (2.03–4.46) | 0.098 |
END, early neurological deterioration; BMI, body mass index; NIHSS, National Institutes of Health Stroke Scale; SSI, single subcortical infarction; CSVD, cerebral small vessel disease; BAD, branch atheromatous disease; LSA, lenticulostriate artery; AChA, anterior choroidal artery; PPA, paramedian pontine arteries; FBG, fasting blood glucose; 2hPBG, 2-h postprandial blood glucose; TC, total cholesterol; TG, triglyceride; HDL, high-density lipoprotein; LDL, low-density lipoprotein; eGFR, estimated glomerular filtration rate; hs-CRP, high-sensitivity C-reactive protein; NLR, neutrophil-to-lymphocyte ratio.