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. 2022 Oct 20;13:1002536. doi: 10.3389/fimmu.2022.1002536

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Copyright © 2022 Zhang, Wen, Hou, Yang, Song, Zeng and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The KEGG metabolic pathway impact analysis. The color and size of each node are based on the p values and pathway impact values, respectively. The “human Homo sapiens (KEGG)” library was selected to perform pathway enrichment analysis and topology analysis. The X-axis presents pathway impact values (based on Out-degree Centrality) and the Y-axis presents the respective p values (based on hypergeometric test). Each circle represents a pathway. The size of circle indicated the pathway impact score, whereas the color represents the p values. Larger circles represent higher impact factors, redder colors represent lower p values. Pathways with p values less than 0.05 were marked by name.