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. 2022 Nov 3;13:6603. doi: 10.1038/s41467-022-34080-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Representative images of spleen tissue and statistical results of spleen weight from Ripk1^+/+ (n = 5) and Ripk1^Y383F/Y383F (n = 5) female mice at age of 6 weeks. b Flow cytometry and statistical analysis of neutrophils (CD11b⁺Ly6G⁺) and monocytes (CD11b⁺Ly6C⁺) in the spleen of Ripk1^+/+ (n = 5) and Ripk1^Y383F/Y383F (n = 5) mice at 8 weeks of age. c Immunohistochemical staining of CD11b, Ly6G, CD45 or F4/80 in liver sections of Ripk1^+/+ and Ripk1^Y383F/Y383F littermate mice at age of 8 weeks (Scale bar, 100 μm). Flow cytometry and statistical analysis in bone marrow for the indicated hematopoietic populations: LKs, LSKs, HSCs (d) and GMPs, MEPs, CMPs (e) from Ripk1^+/+ (n = 5) and Ripk1^Y383F/Y383F (n = 5) mice at age of 8 weeks. f Images of spleen tissue and statistical analysis of spleen weight in Ripk1^+/+ » WT (n = 5) and Ripk1^Y383F/Y383F » WT (n = 5) transplant mice at age of 8 weeks. g Flow cytometry and statistical analysis of neutrophils in the spleen from Ripk1^+/+ » WT (n = 5) and Ripk1^Y383F/Y383F » WT (n = 5) transplant mice at age of 8 weeks. Data are represented as mean ± SEM. Statistical significance was determined using a two-tailed unpaired t test. n.s. p > 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Source data are provided with this paper.