Table 4.

Echocardiographic parameters in OI patients with different genotypes and defects of type I collagen compared with controls.

	OI patients with different genotypes			OI patients with different defects of type I collagen			Controls (n=42)
	COL1A1 mutation (n=39)	COL1A2 mutation (n=10)	Other rare gene mutations (n=8)	Haplo-insufficiency (n=21)	Triple-helical structure change (n=15)	Others (n=13)
PAO (cm)	2.09 ± 0.43	2.10 ± 0.58	2.27 ± 0.30	2.14 ± 0.42	2.01 ± 0.39	2.02 ± 0.47	2.03 ± 0.45
MPA (cm)	1.83 ± 0.31**	1.78 ± 0.29	1.89 ± 0.21	1.84 ± 0.31*	1.91 ± 0.30*	1.75 ± 0.35	1.60 ± 0.32
LAD (cm)	2.62 ± 0.51***	2.55 ± 0.49	2.58 ± 0.53	2.60 ± 0.47**	2.73 ± 0.58**	2.52 ± 0.49	2.11 ± 0.42
LVEDd (cm)	3.90 ± 0.59*	3.78 ± 0.62	3.94 ± 0.45	3.96 ± 0.64*	3.90 ± 0.61	3.63 ± 0.57	3.50 ± 0.62
RVEDd (cm)	1.78 ± 0.38	1.62 ± 0.34	1.96 ± 0.29	1.71 ± 0.33	1.83 ± 0.38	1.73 ± 0.45	1.65 ± 0.22
IVST (cm)	0.57 ± 0.13	0.53 ± 0.12	0.61 ± 0.15	0.58 ± 0.13	0.56 ± 0.13	0.54 ± 0.14	0.67 ± 0.27
LVPWT (cm)	0.56 ± 0.13	0.52 ± 0.12	0.60 ± 0.12	0.58 ± 0.14	0.54 ± 0.12	0.54 ± 0.14	0.67 ± 0.27
LVM (g)	61.34 ± 32.51	51.75 ± 26.12	68.88 ± 30.96	65.21 ± 35.65	58.73 ± 26.05	51.44 ± 31.33	66.17 ± 46.04
HR (bpm)	90.47 ± 17.43	96.38 ± 15.87	87.63 ± 4.93	89.20 ± 15.97	93.77 ± 20.18	92.83 ± 17.34	91.81 ± 20.14
LVEF (%)	68.00 ± 4.40**	70.30 ± 4.30	68.13 ± 4.48	69.00 ± 4.64	69.21 ± 4.19	66.00 ± 3.95**	71.74 ± 5.87

Data were expressed as mean ± standard deviation. OI, osteogenesis imperfecta; PAO, proximal ascending aorta; MPA, main pulmonary artery; LAD, left atrial anteroposterior dimension; LVEDd, left ventricular end-diastolic dimension; RVEDd, right ventricular end-diastolic dimension; IVST, interventricular septal wall thickness; LVPWT, left ventricular posterior wall thickness; LVM, left ventricular mass; HR, heart rate; LVEF, left ventricular ejection fraction.

^*P < 0.05, vs controls; ^**P < 0.01, vs controls; ^***P < 0.001, vs controls.