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. 2022 Oct 20;13:1004946. doi: 10.3389/fendo.2022.1004946

Table 5.

Factors associated with echocardiographic parameters.

Independent variable β (95% CI)
Dependent variable Age Male BSA OI COL1A1 mutation COL1A2 mutation Other genes mutations
PAO 0.699 (0.576, 0.821)*** 2.551 (0.857, 4.246)** 7.649 (6.194, 9.104)*** 0.706 (-1.021, 2.433) 0.214 (-1.629, 2.057) 0.230 (-2.862, 3.322) 2.074 (-1.367, 5.515)
MPA 0.513 (0.419, 0.608)*** 1.496 (0.201, 2.792)* 5.942 (4.888, 6.995)*** 2.341 (1.122, 3.561)*** 1.565 (0.236, 2.895)* 0.479 (-1.813, 2.771) 2.403 (-0.122, 4.927)
LAD 0.816 (0.660, 0.972) 2.108 (0.001, 4.214) 9.066 (7.237, 10.896)*** 4.754 (2.865, 6.643)*** 3.796 (1.708, 5.884)*** 1.253 (-2.476, 4.982) 3.074 (-1.069, 7.217)
LVEDd 1.040 (0.870, 1.203)*** 2.541 (0.079, 5.003)* 12.041 (10.224, 13.858)*** 3.532 (1.167, 5.897)** 2.807 (0.258, 5.355)* 0.142 (-4.241, 4.525) 3.597 (-1.261, 8.455)
RVEDd 0.466 (0.338, 0.595)*** 0.683 (0.874, 2.240) 5.858 (4.477, 7.238)*** 1.236 (-0.412, 2.885) 0.841 (-0.670, 2.353) -1.322 (-3.673, 1.029) 2.400 (-1.191, 4.991)
IVST 0.303 (0.246, 0.361)*** 1.057 (0.255, 1.858)* 3.430 (2.778, 4.081)*** -1.053 (-1.913, -0.192)* -0.585 (0.172, -1.430) -0.748 (-2.068, 0.573) 0.164 (-1.323, 1.652)
LVPWT 0.304 (0.247, 0.362)*** 0.994 (0.133, 1.075)* 3.480 (2.835, 4.125)*** -1.169 (-2.025, -0.312)** -0.594 (-1.435, 0.248) -0.810 (-2.124, 0.503) 0.069 (-1.414, 1.551)
LVM 6.356 (5.377, 7.335)*** 16.117 (0.329, 31.904)* 73.895 (63.244, 84.545)*** -6.888 (-24.094, 10.318) -1.986 (-18.447, 14.475) -12.003 (-37.480, 13.473) 7.186 (-21.405, 35.777)
LVEF 0.194 (-0.026, 0.415) -0.407 (-2.559, 1.745) 1.604 (-0.923, 4.132) -3.341 (-5.350, -1.332)** -3.269 (-5.430, -1.107)** 0.973 (-2.818, 4.764) -1.583 (-5.826, 2.661)

BSA, body surface area; OI, osteogenesis imperfecta; PAO, proximal ascending aorta; MPA, main pulmonary artery; LAD, left atrial anteroposterior dimension; LVEDd, left ventricular end-diastolic dimension; RVEDd, right ventricular end-diastolic dimension; IVST, interventricular septal wall thickness; LVPWT, left ventricular posterior wall thickness; LVM, left ventricular mass; LVEF, left ventricular ejection fraction.

β, Regression coefficient. *P < 0.05; **P < 0.01; ***P < 0.001.