TABLE 2.
Mean a plasma high sensitivity C-reactive protein (hsCRP) concentrations according to categories of DNA base excision repair (BER) and antioxidant enzyme (AE) genetic risk scores (GRS), in the pooled MAP I and MAP II cross-sectional studies.
| GRS, GRS categories | GRS category medians | Plasma hsCRP, µg/mL | |||
|---|---|---|---|---|---|
| n | Mean (95% CI) a | Prop. diff. b (%) | P a | ||
| BER GRS c | |||||
| Tertiles | |||||
| 1 | 0 | 151 | 2.2 (1.9, 2.7) | Ref. | |
| 2 | 1 | 113 | 3.0 (2.5, 3.7) | 35.8 | |
| 3 | 2 | 69 | 3.5 (2.7, 4.6) | 57.4 | 0.009 |
| AE GRS d | |||||
| Low | −2 | 200 | 2.6 (2.2, 3.0) | Ref. | |
| High | 3 | 133 | 2.9 (2.4, 3.6) | 13.9 | 0.30 |
Abbreviations: AE, antioxidant enzyme; BER, base excision repair; CI, confidence interval; GRS, genetic risk score; hsCRP, high sensitivity C-reactive protein; MAP, Markers of Adenomatous Polyps; Prop. diff., proportional difference; Ref., reference.
Geometric means, 95% confidence intervals, and p-values for mean differences from crude general linear models; unequal sample sizes in tertiles due to ranking ties; differences in the numbers of participants due to availability of blood samples for assays.
Proportional difference calculated as (comparison group mean-reference group mean)/(reference group mean) x 100%.
BER genetic risk score based on 7 SNPs in 5 BER genes; see complete list of genes and SNPs in the text and Supplementary Table S7; a higher GRS indicates a higher number of variant relative to common alleles.
AE genetic risk score based on 2 SNPs in 2 AE genes; see complete list of genes and SNPs in the text and Supplementary Table S6; a higher GRS indicates a higher number of variant relative to common alleles.