TABLE 1.
Clinical demographic for each study participant eye
| Patient | Eye_ID | Disease | Eye | Gender | Age at Dx (mos) | Treatment when sample collected |
|---|---|---|---|---|---|---|
| CAT_01 | CAT_01_OD | CAT | OD | Male | 168 | CE/AV/IOL |
| CAT_01 | CAT_01_OS | CAT | OS | Male | 168 | CE/AV/IOL |
| CAT_02 | CAT_02_OD | CAT | OD | Male | 1 | CE/AV |
| CAT_03 | CAT_03_OD | CAT | OD | Male | 4 | CE/AV |
| GLC_01 | GLC_01_OD | GLC | OD | Male | 4 | Trabeculotomy |
| GLC_01 | GLC_01_OS | GLC | OS | Male | 4 | Trabeculotomy |
| GLC_02 | GLC_02_OD | GLC | OD | Female | 50 | Trabeculotomy |
| GLC_03 | GLC_03_OD | GLC | OD | Female | 168 | Trabeculotomy |
| GLC_03 | GLC_03_OS | GLC | OS | Female | 168 | Trabeculotomy |
| GLC_04 | GLC_04_OD | GLC | OD | Female | 196 | Aqueous shunt revision right eye |
| PRD_01 | PRD_01_OSA | PRD | OS | Male | 179 | Vitrectomy |
| PRD_01 | PRD_01_OSB | PRD | OS | Male | 179 | Vitrectomy |
| PRD_02 | PRD_02_OD | PRD | OD | Male | 138 | Vitrectomy, lensectomy |
| PRD_03 | PRD_03_OD | PRD | OD | Male | 15 | pars plana vitrectomy OD |
| Rb_01 | Rb_01_OD | Rb | OD | Female | 2 | Secondary enucleation |
| Rb_02 | Rb_02_OD | Rb | OD | Female | 4 | Diagnosis |
| Rb_02 | Rb_02_OS | Rb | OS | Female | 4 | Diagnosis |
| Rb_03 | Rb_03_OSD | Rb | OS | Male | 22 | Diagnosis |
| Rb_03 | Rb_03_OSC | Rb | OS | Male | 22 | Carboplatin |
| Rb_03 | Rb_03_OSE | Rb | OS | Male | 22 | Secondary enucleation |
| Rb_04 | Rb_04_OD | Rb | OD | Male | 30 | Intra‐arterial chemotherapy for salvage |
| Rb_05 | Rb_05_OD | Rb | OD | Male | 25 | Primary enuleation |
| Rb_06 | Rb_06_OD | Rb | OD | Male | 9 | Carboplatin, etoposide, vincristine systemic chemotherapy for salvage |
| Rb_06 | Rb_06_OS | Rb | OS | Male | 9 | Carboplatin, etoposide, vincristine systemic chemotherapy for salvage |
| Rb_07 | Rb_07_OS | Rb | OS | Male | 24 | Diagnosis |
| Rb_08 | Rb_08_OD | Rb | OD | Female | 24 | Primary enuleation |
| Rb_09 | Rb_09_OD | Rb | OD | Male | 2 | Diagnosis |
| Study group comparison | |||
|---|---|---|---|
| P‐Value | Eye (Fisher) | Gender (Fisher) | Age at Dx (MWU) |
| Normal (14) vs. Tumor (13) | 0.704 | 0.999 | 0.045* |
| Retina (17) vs. Non‐Retina (10) | 0.448 | 0.415 | 0.464 |
| Rb naïve (7) vs. Treatment active (6) | 0.999 | 0.559 | 0.960 |
Abbreviations: CAT, congenital cataract; GLC, congenital glaucoma; PRD, pediatric retinal disease; Rb, retinoblastoma; OD, oculus dextrus; OS, oculus sinister; CE, cataract extraction; AV, anterior vitrectomy; IOL, intraocular lens.
Normal (CAT+GLC+PRD), Tumor (Rb); Retina (Rb+PRD), Non‐retina (CAT+GLC); Rb naïve (Diagnosis+Primary enucleation), Treatment active (Secondary enucleation+chemotherapy); Fisher (Fisher's extract test), MWU (Mann‐Whitney U test).