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. 2013 Dec 19;123(8):1129–1136. doi: 10.1182/blood-2013-08-521419

Figure 4.

Figure 4

B abortus –treated mice have shortened RBC lifespan and evidence of hemolysis. (A) The RBC biotinylation assay indicates a 2.7-fold increase in RBC destruction in B abortus – treated mice (−4%/day vs −1.7%/day). Means ± SD. *P < .05 and **P < .001 by Student t test or Mann-Whitney U test. Overall difference between the 2 sets of measurements is significant at P < .001 by 2-way analysis of variance (Holm-Sidak method). (B) Peripheral blood smears of B abortus – injected mice 2 weeks after showing schistocytes and erythrocyte membrane irregularities, consistent with mild microangiopathic hemolysis. Arrows point to damaged erythrocytes, shown magnified in the right margin.