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. 2022 Nov 3;17(11):e0275258. doi: 10.1371/journal.pone.0275258

Fig 9. Leonurine inhibited pyroptosis by regulating TGF-β/Smad2 signalling pathway in H9c2 cells stimulated by TGF-β.

Fig 9

(A) Compared to H9c2 cells induced by TGF-β for thirty minutes, leonurine decreased the expressions of Smad2 phosphorylation and cleaved Caspase 1 (B) The ratio of Smad2 phosphorylation to Smad2 expression and the ratio of cleaved Caspase 1 to Caspase 1 expression. (C) The fluorescence of Smad2 protein was detected under a confocal laser scanning microscope. Compare to TGF-β induced model group, the intensity fluorescence of Smad2 protein was weakened after leonurine treatment. #P<0.05, ##P<0.01, model group vs. control group; *P<0.05, ***P<0.001, 20 μM leonurine group vs. model group.