Table 6.
Summary of evidence of included SRs.
| Included study | Outcomes | GRADE assessment | Relative effect (95% CI) | P value | Certainty | ||||
|---|---|---|---|---|---|---|---|---|---|
| Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | |||||
| Acupuncture or electroacupuncture VS Antihistamine | |||||||||
|
| |||||||||
| Li [24] (2009) | Curing rate | serious | No | no | serious | strongly suspected | RR = 2.14, 95%CI (1.64 to 2.79) | P < 0.0001 | VERY LOW |
| Yao [22] (2016) | Total effective rate | serious | No | no | serious | strongly suspected | RR = 1.37, 95%CI (1.11 to 1.70) | P=0.003 | VERY LOW |
| Yan [19] (2015) | Total effective rate | serious | No | no | serious | strongly suspected | RR = 1.21, 95%CI (1.00 to 1.46) | P=0.05 | VERY LOW |
| Zhao [40] (2019) | Total effective rate | serious | No | no | serious | strongly suspected | OR = 2.19, 95%CI (0.79 to 6.07) | P=0.13 | VERY LOW |
|
| |||||||||
| Acupuncture or electroacupuncture combined with antihistamine VS Antihistamine | |||||||||
|
| |||||||||
| Li [24] (2009) | Curing rate | serious | No | no | serious | strongly suspected | RR = 2.03, 95%CI (1.35 to 3.06) | P=0.0006 | VERY LOW |
| Recurrence rate | serious | No | no | no | strongly suspected | RR = 0.35, 95%CI (0.13 to 0.93) | P=0.03 | LOW | |
| Yao [22] (2016) | Total effective rate | serious | no | no | serious | strongly suspected | RR = 1.77, 95%CI (1.41 to 2.22) | P < 0.01 | VERY LOW |
| Yan [19] (2015) | Total effective rate | serious | no | no | serious | strongly suspected | RR = 1.20, 95%CI (1.07 to 1.35) | P=0.002 | VERY LOW |
| Zhao [40] (2019) | Total effective rate | serious | no | no | serious | strongly suspected | OR = 6.59, 95%CI (2.69 to 16.16) | P < 0.0001 | VERY LOW |
|
| |||||||||
| Acupuncture combined with other therapies VS Antihistamine | |||||||||
|
| |||||||||
| Ke [25] (2021) | Total effective rate | serious | no | no | serious | undetected | RR = 1.35, 95%CI (1.24 to 1.47) | P < 0.0001 | VERY LOW |
| Zhao [40] (2019) | Total effective rate | serious | no | no | serious | strongly suspected | OR = 4.35, 95%CI (2.41 to 7.86) | P < 0.0001 | VERY LOW |
| Curing rate | serious | no | no | serious | strongly suspected | OR = 2.44, 95%CI (1.80 to 3.31) | P < 0.0001 | VERY LOW | |
| IgE | serious | no | no | serious | strongly suspected | SMD = -1.71, 95%CI (-2.12 to -1.29) | P < 0.0001 | VERY LOW | |
| Recurrence rate | serious | no | no | serious | strongly suspected | OR = 0.28, 95%CI (0.14 to 0.55) | P=0.0003 | VERY LOW | |
| Zhao [27] (2020) | Total effective rate | serious | no | no | serious | strongly suspected | RR = 3.85, 95%CI (2.61 to 5.69) | P < 0.0001 | VERY LOW |
| Recurrence rate | serious | no | no | no | strongly suspected | OR = 0.28, 95%CI (0.14 to 0.55) | P=0.0003 | LOW | |
|
| |||||||||
| Acupuncture or Acupuncture combined with other therapies vs. Western medicine | |||||||||
|
| |||||||||
| Zhang [34] (2020) | Total effective rate | serious | no | no | no | undetected | OR = 3.86, 95%CI (2.71 to 5.49) | P < 0.0001 | MODERATE |
| Recurrence rate | serious | no | no | no | undetected | OR = 0.34, 95%CI (0.16 to 0.72) | P=0.005 | MODERATE | |
| Curing rate | serious | no | no | no | undetected | OR = 2.23, 95%CI (1.75 to 2.85) | P < 0.0001 | MODERATE | |
|
| |||||||||
| Bloodletting VS Antihistamine | |||||||||
|
| |||||||||
| Yao [20] (2019) | Disease activity control | serious | no | no | serious | strongly suspected | MD = 0.67, 95%CI (0.03 to 1.31) | P=0.04 | VERY LOW |
| Total effective rate | serious | no | no | serious | strongly suspected | RR = 1.10, 95%CI (0.97 to 1.26) | P=0.15 | VERY LOW | |
|
| |||||||||
| Bloodletting combined with antihistamine VS Antihistamine | |||||||||
|
| |||||||||
| Yao [20] (2019) | Total effective rate | serious | no | no | serious | strongly suspected | RR = 1.34, 95%CI (1.10 to 1.63) | P=0.003 | VERY LOW |
|
| |||||||||
| Cupping VS Antihistamine | |||||||||
|
| |||||||||
| Xiao [23] (2020) | Total effective rate | very serious | serious | no | serious | undetected | RR = 1.10, 95%CI (0.97 to 1.25) | P=0.14 | VERY LOW |
| Recurrence rate | very serious | no | no | serious | undetected | RR = 0.56, 95%CI (0.23 to 1.36) | P=0.20 | VERY LOW | |
|
| |||||||||
| Cupping combined with antihistamine VS Antihistamine | |||||||||
|
| |||||||||
| Xiao [23] (2020) | Total effective rate | very serious | serious | no | serious | undetected | RR = 1.18, 95%CI (1.01 to 1.39) | P=0.03 | VERY LOW |
| Recurrence rate | very serious | no | no | serious | undetected | RR = 0.52, 95%CI (0.32 to 0.84) | P=0.007 | VERY LOW | |
|
| |||||||||
| Cupping combined with acupuncture VS Acupuncture | |||||||||
|
| |||||||||
| Xiao [23] (2020) | Total effective rate | very serious | serious | no | serious | undetected | RR = 1.25, 95%CI (1.07 to 1.46) | P=0.006 | VERY LOW |
|
| |||||||||
| Autohemotherapy vs. Placebo | |||||||||
|
| |||||||||
| Liang [41] (2016) | Total effective rate | serious | very serious | no | serious | strongly suspected | RR = 1.51, 95%CI (1.06 to 2.14) | P=0.02 | VERY LOW |
|
| |||||||||
| Autohemotherapy vs. Antihistamine | |||||||||
|
| |||||||||
| Luo [39] (2016) | Total effective rate | very serious | serious | no | serious | strongly suspected | RR = 1.05, 95%CI (0.97 to 1.13) | P=0.21 | VERY LOW |
| Clinical efficacy rate | very serious | serious | no | serious | strongly suspected | RR = 1.12, 95%CI (0.98 to 1.28) | P=0.21 | VERY LOW | |
| Liang [41] (2016) | Total effective rate | serious | very serious | no | serious | strongly suspected | RR = 1.14, 95%CI (1.04 to 1.26) | P=0.05 | VERY LOW |
| IgE | serious | very serious | no | serious | strongly suspected | RR = -11.15, 95%CI (-55.62 to 33.32) | P=0.62 | VERY LOW | |
| Zhao [30] (2019) | Total effective rate | serious | no | no | serious | strongly suspected | RR = 1.28, 95%CI (1.17 to 1.40) | P < 0.00001 | VERY LOW |
| Curing rate | serious | no | no | serious | strongly suspected | RR = 1.27, 95%CI (1.13 to 1.44) | P < 0.0001 | VERY LOW | |
| Recurrence rate | serious | no | no | serious | strongly suspected | RR = 0.34, 95%CI (0.26 to 0.46) | P < 0.00001 | VERY LOW | |
|
| |||||||||
| Autohemotherapy vs. Other treatment | |||||||||
|
| |||||||||
| An [38] (2016) | Total effective rate | very serious | serious | no | serious | strongly suspected | RR = 1.08, 95%CI (1.12 to 1.15) | P=0.006 | VERY LOW |
| Recurrence rate | very serious | serious | no | serious | strongly suspected | RR = 0.46, 95%CI (0.26 to 0.81) | P=0.007 | VERY LOW | |
| Luo [39] (2016) | Total effective rate | very serious | serious | no | serious | strongly suspected | RR = 1.07, 95%CI (0.88 to 1.29) | P=0.51 | VERY LOW |
| Clinical efficacy rate | very serious | serious | no | serious | strongly suspected | RR = 1.36, 95%CI (0.95 to 1.96) | P=0.10 | VERY LOW | |
| Pu [28] (2017) | Clinical efficacy rate | serious | no | no | serious | strongly suspected | RR = 1.13, 95%CI (1.07 to 1.19) | P < 0.00001 | VERY LOW |
| Recurrence rate | serious | no | no | serious | strongly suspected | RR = 0.32, 95%CI (0.21 to 0.48) | P < 0.00001 | VERY LOW | |
| Zhao [30] (2019) | Total effective rate | serious | no | no | serious | strongly suspected | RR = 1.28, 95%CI (1.11 to 1.47) | P=0.0006 | VERY LOW |
| Curing rate | serious | no | no | serious | strongly suspected | RR = 1.33, 95%CI (1.05 to 1.69) | P=0.02 | VERY LOW | |
|
| |||||||||
| Autohemotherapy combined with antihistamine vs. Antihistamine | |||||||||
|
| |||||||||
| Yan [19] (2015) | Total effective rate | serious | no | no | serious | strongly suspected | RR = 1.06, 95%CI (0.98 to 1.14) | P=0.13 | VERY LOW |
| Dermatology Quality Life Index | serious | no | no | serious | strongly suspected | MD = 0.90, 95%CI (1.34 to 0.46) | P < 0.0001 | VERY LOW | |
| Luo [39] (2016) | Recurrence rate | very serious | serious | no | serious | strongly suspected | RR = 0.10, 95%CI (0.98 to 1.28) | P < 0.00001 | VERY LOW |
| Liang [41] (2016) | Total effective rate | serious | very serious | no | serious | strongly suspected | RR = 1.09, 95%CI (0.93 to 1.27) | P=0.27 | VERY LOW |
| Recurrence rate | serious | no | no | serious | strongly suspected | RR = 0.36, 95%CI (0.23 to 0.55) | P < 0.0001 | VERY LOW | |
| Wu [29] (2019) | Total effective rate | serious | serious | no | serious | undetected | RR = 1.25, 95%CI (1.19 to 1.32) | P < 0.001 | VERY LOW |
| Recurrence rate | serious | no | no | serious | undetected | RR = 0.30, 95%CI (0.22 to 0.39) | P < 0.001 | LOW | |
|
| |||||||||
| Autohemotherapy combined with herbal medicine vs. Herbal medicine | |||||||||
|
| |||||||||
| Yan [19] (2015) | Total effective rate | serious | no | no | serious | strongly suspected | RR = 1.30, 95% CI (1.10, 1.55) | P=0.002 | VERY LOW |
| Luo [39] (2016) | Total effective rate | very serious | serious | no | serious | strongly suspected | RR = 1.30, 95% CI (1.10, 1.55) | P=0.002 | VERY LOW |
| Clinical efficacy rate | very serious | serious | no | serious | strongly suspected | RR = 1.52, 95% CI (1.20, 1.94) | P=0.0006 | VERY LOW | |
|
| |||||||||
| Catgut embedding vs. Other therapy | |||||||||
|
| |||||||||
| Wei [26] (2019) | Clinical efficacy rate | serious | no | no | serious | strongly suspected | RR = 1.1, 95% CI (1.03 to 1.16) | P=0.002 | VERY LOW |
| Curing rate | serious | no | no | serious | undetected | RR = 1.59, 95%CI (1.30 to 1.95) | P < 0.00001 | LOW | |
| Recurrence rate | serious | no | no | serious | strongly suspected | RR = 0.49, 95%CI (0.27 to 0.86) | P=0.01 | VERY LOW | |
|
| |||||||||
| Catgut embedding combined with antihistamine vs. Antihistamine | |||||||||
|
| |||||||||
| Yan [19] (2015) | Total effective rate | serious | no | no | serious | strongly suspected | RR = 1.14, 95%CI (0.98 to 1.34) | P=0.10 | VERY LOW |
|
| |||||||||
| Auriculotherapy or auriculotherapy combined with other therapies vs. Western medicine | |||||||||
|
| |||||||||
| Zhu [21] (2018) | Improving clinical signs and symptoms | serious | serious | no | serious | strongly suspected | OR = 0.74, 95%CI (0.35 to 1.56) | P=0.42 | VERY LOW |
| Clinical efficacy rate | serious | no | no | serious | strongly suspected | OR = 3.81, 95%CI (2.07 to 7.01) | P < 0.0001 | VERY LOW | |
|
| |||||||||
| Acupoint injection combined with western medicine vs. Western medicine | |||||||||
|
| |||||||||
| Yan [19] (2015) | Total effective rate | serious | no | no | serious | strongly suspected | RR = 1.07, 95%CI (0.99 to 1.17) | P=0.09 | VERY LOW |
Note. CI, confidence interval; OR, odds ratio; RR, relative risk; MD, mean difference; SMD, standardized mean difference.