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. 2022 Oct 20;16:1003522. doi: 10.3389/fnins.2022.1003522

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Copyright © 2022 Moses, Sinclair, Schwartz, Silbert, O’Brien, Law and Vivash.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Perivascular spaces measurements and NIH cognition total composite score. Demonstrates a significant relationship between PVS measurements and cognition as measured by the NIH cognition total composite score (n = 10). The PVS cluster number and PVS volume were both adjusted by white matter volume. (A) PVS cluster number and cognition total composite score. (B) PVS volume and cognition total composite score. (C) The change in PVS cluster numbers and the change in cognition total composite scores longitudinally. (D) The change in PVS volume and the change in cognition total composite scores longitudinally. Individual participants are depicted as blue dots. The gray band represents the 95% confidence interval, and the black line represents the estimated mean.