TABLE 4.
Perivascular space measurements and cognition and disease severity.
| PVS cluster number | PVS volume | |||||
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| ß Estimate | Confidence Interval | P-value | ß Estimate | Confidence interval | P-value | |
| NUCOG | −0.016 | −0.046 – 0.014 | 0.323 | −1.21e–3 | −3.96e–3 – 1.53e–3 | 0.402 |
| Cognitive Total Composite Score | −0.802e–3 | 9.45e–3 – −6.60e–3 | < 0.001*** | −1.30e–3 | −1.55e–3 – −1.05e–3 | <0.001*** |
| CBS | 5.41e–4 | −0.021 – 0.022 | 0.962 | 1.24e–4 | −1.95e–3 – 2.20e–3 | 0.909 |
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| Change in PVS Cluster Number | Change in PVS Volume | |||||
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| ß Estimate | Confidence Interval | P-value | ß Estimate | Confidence Interval | P-value | |
|
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| Change in NUCOG | −0.028 | −0.071 – 0.015 | 0.224 | −2.09e–3 | −6.48e–3 – 2.30e–3 | 0.373 |
| Change in Cognition Total Composite | 0.047 | 0.005 – 0.088 | 0.078^ | 4.36e–3 | 1.33e–3 – 7.40e–3 | 0.046* |
| Change in CBS | −0.015 | −0.053 – 0.024 | 0.474 | 7.37e–5 | −3.81e–3 – 3.95e–3 | 0.971 |
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| PVS Cluster Number | PVS Volume | |||||
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| ß Estimate | Confidence Interval | P-value | ß Estimate | Confidence Interval | P-value | |
|
| ||||||
| NUCOG | −0.016 | −0.046 – 0.014 | 0.323 | −1.21e–3 | −3.96e–3 – 1.53e–3 | 0.402 |
| Cognitive Total Composite Score | −0.802e–3 | 9.45e–3 – −6.60e–3 | <0.001*** | −1.30e–3 | −1.55e–3 – −1.05e–3 | < 0.001*** |
| CBS | 5.41e–4 | −0.021 – 0.022 | 0.962 | 1.24e–4 | −1.95e–3 – 2.20e–3 | 0.909 |
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| Change in PVS Cluster Number | Change in PVS Volume | |||||
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| ß Estimate | Confidence Interval | P-value | ß Estimate | Confidence Interval | P-value | |
|
| ||||||
| Change in NUCOG | −0.028 | −0.071 – 0.015 | 0.224 | −2.09e–3 | −6.48e–3 – 2.30e–3 | 0.373 |
| Change in Cognition Total Composite | 0.047 | 0.005 – 0.088 | 0.078^ | 4.36e–3 | 1.33e–3 – 7.40e–3 | 0.046* |
| Change in CBS | −0.015 | −0.053 – 0.024 | 0.474 | 7.37e–5 | −3.81e–3 – 3.95e–3 | 0.971 |
The β estimate, 95% confidence interval, and p-values for the relationship between PVS measurements and cognition, and disease severity are shown. ***P-value < 0.001, **p-value < 0.01, *p-value < 0.05, ^p-value < 0.1.