TABLE 5.

Perivascular space measurements and protein biomarkers.

	PVS cluster number			PVS volume
	ß Estimate	Confidence Interval	P-value	ß Estimate	Confidence Interval	P-value
CSF t-tau	2.845	0.630 – 5.06	0.036*	28.4	−2.28 – 59.0	0.106
Serum t-tau	−202	−560 – 154	0.288	−2179	−5759 – 1401	0.286
Plasma t-tau	122	−0.427 – 245	0.079^	1408	221 – 2594	0.052^
NfL	−0.074	−0.218 – 0.070	0.332	−0.916	−2.66 – 0.825	0.328
	Change in PVS cluster number			Change in PVS volume
	ß Estimate	Confidence Interval	P-value	ß Estimate	Confidence Interval	P-value
Change in CSF t-tau	1.54	0.918 – 2.16	< 0.001***	13.8	6.37 – 21.1	0.003**
Change in Serum t-tau	−153	−289 – −17.5	0.051^	−1387	−2723 – −50.9	0.076^
Change in Plasma t-tau	25.2	−13.7 – 64.1	0.227	239	−164 – 642	0.266
Change in NfL	0.101	5.93e–3 – 0.196	0.085^	1.40	0.272 – 2.52	0.045*

The β estimate, 95% confidence interval, and p-values for the relationship between PVS measurements and protein biomarkers are shown. ***P-value < 0.001, **p-value < 0.01, *p-value < 0.05, ^p-value < 0.1.