FIGURE 2.

Ceritinib resistance was induced by ligand‐dependent activation of FGFR3 in the H3122 LR3 cells. A, C, The H3122 and H3122 LR3 cells were treated with various concentrations of ceritinib with or without erlotinib (1 μM), cabozantinib (1 μM), or infigratinib (100 nM) for 72 h. B, The phosphorylation levels of 49 RTKs in the H3122 and H3122 LR3 cells were measured using an RTK array with cell lysates treated with or without 1 μM of ceritinib for 8 h. D, The H3122 LR3 cells were treated with ceritinib (1 μM) with or without infigratinib (100 nM) for 1–48 h. After incubation, the cells were lysed and analyzed by immunoblotting.