FIGURE 1.

Establishment of a biobank of pediatric ALL PDX models. (A) Engraftment of leukemia cells in PDX mice over time. Primary leukemic cells were transplanted into recipient mice, and the proportions of human CD19‐ or CD3‐positive ALL cells were detected in BM by flow cytometry. Each line represents data from a single mouse. (B) In vivo expansion rate of leukemic cells. Numbers above are mean expansion rates with standard deviation. BM (B‐ALL, n = 14), CSF (B‐ALL, n = 3; T‐ALL, n = 2), and testis (B‐ALL, n = 1).