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. 2022 Aug 30;113(11):3814–3825. doi: 10.1111/cas.15506

FIGURE 2.

FIGURE 2

PDX mice preserve the characteristics of primary samples. (A–D) Immunohistochemical analysis of leukemic cell proliferation in (A) spleen, (B) liver, (C) brain, and (D) testis from a xenograft mouse generated from a sample from patient ALL#25 relapsed in testis. (E) Unsupervised hierarchical clustering of expression of patterns using DNA microarray data among four primary ALL samples and the corresponding PDX cells derived from BM and spleen.