Table 2:
Enrichment of recurrent CNVs in EOP relative to ASD and Unselected Control Cohorts
| ASD Contrast | ASD carriers | EOP carriers | OR | 95%CI | P-value |
|---|---|---|---|---|---|
| EOP (N=137) | 193 | 11 | 2.42 | 1.16-4.57 | 0.02 |
| EOP without ASD (N=90) | 193 | 6 | 1.79 | 0.63-4.11 | 0.16 |
| EOP without ID (N=120) | 193 | 7 | 1.72 | 0.67-3.72 | 0.20 |
| EOP without schizophrenia (N=99) | 193 | 8 | 2.43 | 1.01-5.10 | 0.02 |
| EOP < 13 years old (N=101) | 193 | 6 | 1.75 | 0.62-4.02 | 0.17 |
| Control Contrast | Control carriers | EOP carriers | OR | 95%CI | P-value |
| EOP (N=137) | 273 | 11 | 5.19 | 2.50-9.75 | 2 × 10−5 |
| EOP without ASD (N=90) | 273 | 6 | 3.83 | 1.36-8.77 | 6 × 10−3 |
| EOP without ID (N=120) | 273 | 7 | 3.68 | 1.43-7.94 | 4 × 10−3 |
| EOP without schizophrenia (N=99) | 273 | 8 | 5.22 | 2.17-10.88 | 3 × 10−4 |
| EOP < 13 years old (N=101) | 273 | 6 | 3.75 | 1.33-8.58 | 7 × 10−3 |
Legend: Odds ratios are computed using Fisher’s exact test. Significant p-values are in bold (≤ 0.05). Sensitivity analysis involved excluding individuals in the EOP sample: 1) with co-occurring ASD; 2) with co-occurring ID; 3) with a diagnosis of schizophrenia; or 5) with psychosis onset prior to age 13. EOP: early-onset psychosis; ASD: autism spectrum disorder (N=5,540); Controls: unselected population (N=16,504); ID: intellectual disability; N: number of individuals; OR: Odds ratio; 95% CI: 95% confidence intervals.