Skip to main content
. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Obesity (Silver Spring). 2022 Sep 25;30(11):2294–2306. doi: 10.1002/oby.23549

Figure 5. Predictive performance of obesity metabolomic signatures for risk of type 2 diabetes.

Figure 5.

Abbreviations: BMI, body mass index; MES, metabolomic signature; ROC, receiver operating characteristic; WC, waist circumference. Traditional risk factors included age, sex, smoking, pack-years among ever smokers, alcohol drinking, diet quality, physical activity, family history of diabetes, BMI, and WC. Plasma glucose was represented by a composite glucose/fructose/galactose level in the metabolomics data. The prediction performance of obesity MESs alone and in addition to traditional T2D risk factors was assessed by computing the C-statistics (i.e., area under the ROC curve). p≥0.12 for pairwise comparisons in Figure 5A, and p=0.22 for comparison between the first two models, and ≤0.003 for other pairwise comparisons in Figure 5B.