Table 2.
Use of nonsteroidal anti-inflammatory drugs, acetaminophen, and risk of melanoma among 58,227 non-Hispanic white participants in the US Radiologic Technologists Study
| Person-years | No. with casesa | RRb | 95% CI | |
|---|---|---|---|---|
| NSAIDs | ||||
| No | 129,148 | 98 | 1 (ref.) | |
| Yes, any | 799,011 | 510 | 0.87 | (0.71, 1.09) |
| Aspirin, days per month | ||||
| No | 401,495 | 256 | 1 (ref.) | |
| <1 | 121,247 | 69 | 0.83 | (0.63, 1.07) |
| 1–4 | 163,161 | 116 | 1.05 | (0.84, 1.30) |
| ≥5 | 169,964 | 118 | 0.93 | (0.74, 1.16) |
| Other NSAIDs (e.g., ibuprofen, naproxen), days per month | ||||
| No | 252,517 | 183 | 1 (ref.) | |
| <1 | 103,643 | 66 | 0.93 | (0.70, 1.23) |
| 1–4 | 234,239 | 144 | 0.97 | (0.78, 1.21) |
| ≥5 | 299,096 | 195 | 1.02 | (0.83, 1.25) |
| Any acetaminophen | ||||
| No | 250,441 | 169 | 1 (ref.) | |
| Yes, any | 619,109 | 389 | 1.03 | (0.86, 1.24) |
| Acetaminophen, days per month | ||||
| No | 250,441 | 169 | 1 (ref.) | |
| <1 | 153,384 | 101 | 1.03 | (0.80, 1.32) |
| 1–4 | 271,536 | 185 | 1.13 | (0.92, 1.40) |
| ≥5 | 194,189 | 103 | 0.89 | (0.69, 1.13) |
Abbreviations: NSAIDs, nonsteroidal anti-inflammatory drugs; RR, rate ratio; CI, confidence interval.
a
Numbers may be inconsistent because of missing values.
b
Adjusted for attained age, sex, birth cohort (<1941, 1941–1945, 1946–1950, 1951–1955, 1956+), and quartile of lifetime average annual ambient UVR (ordinal).
Note: For trend tests, categories of medication use frequency was coded ordinally with all P-values >0.05.