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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Nat Chem. 2022 Sep 26;14(11):1270–1277. doi: 10.1038/s41557-022-01027-7

Fig. 1. The structures of (+) pleuromutilin (1), clinically relevant derivatives, and prior synthetic art.

Fig. 1.

a. Structures of (+)-pleuromutilin (1), 12-epi-pleuromutilin (2), retapamulin (3), lefamulin (4), and extended spectrum pleuromutilins (ESPs, 5). b. Overview of the prior synthetic route to (+)-pleuromutilin (1) by Murphy et al.18