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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Nat Chem. 2022 Sep 26;14(11):1270–1277. doi: 10.1038/s41557-022-01027-7

Fig. 3. Scope of the butynylation reaction, competition of a fully derivatized analog and synthesis of a C7-substitued pleuromutilin.

Fig. 3.

a. Products synthesized by addition to 20. Isolated yields and diastereoselectivity are reported. b. Synthesis of the C12 normethyl lefamulin derivative 37. c. Synthesis of the C7-substituted derivative 45.