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. 2022 Nov 3;13:6427. doi: 10.1038/s41467-022-33797-6

Fig. 4. Correlations of cerebrospinal fluid C4A and C4B protein concentration with markers of synapse density.

Fig. 4

Cerebrospinal fluid (CSF) from 19 healthy controls, 14 patients with first-episode psychosis (FEP) who developed schizophrenia and 29 patients with first-episode psychosis (FEP) who developed schizophrenia in the KaSP cohort were analyzed. Median age: 27 years (interquartile range 22–32), 40 males and 22 females. CSF C4A levels (adjusted for age, sex, and diagnosis) were negatively correlated to CSF levels of neuronal pentraxin 1 [r(adjusted) = −0.30, P(adjusted) = 0.026; a], neuronal pentraxin 2 [r(adjusted) = −0.26; P(adjusted) = 0.026; b], and neuronal pentraxin receptor [r = −0.34; P(adjusted) = 0.040; c]. All correlations were analyzed using Spearman’s partial correlation analyses. All reported P values are two sided and adjusted for multiple testing using Benjamini-Hochberg correction. Intercepts and 95% confidence intervals are indicated in the graphs. Source data for the graphs are provided in the Source Data file.