Table 1.

Correlations of CSF C4A and C4B concentration to the Positive and Negative Syndrome Scale (PANSS) scores, and performance in the key domains of the MATRICS Consensus Cognitive Battery (MCCB)

		C4A		C4B
		FEP-nSCZ	FEP-SCZ	FEP-nSCZ	FEP-SCZ
Positive and Negative Symptom Scale; PANSS
Positive sub-scale	r	−0.035	−0.27	0.05	0.19
	P	0.906	0.136	0.863	0.435
	N	15	29	15	28
Negative sub-scale	r	0.10	−0.25	−0.23	0,00083
	P	0.906	0.218	0.567	0.997
	N	15	29	15	28
General sub-scale	r	0.04	−0.02	−0.52	0.29
	P	0.906	0.997	0.168	0.435
	N	15	29	15	28
MATRICS Consensus Cognitive Battery (MCCB)
TMT	r	−0.45	0.05	0.01	−0.14
	P	0.32	0.817	0.992	0.971
	N	15	27	15	26
BACS-SC	r	0.19	0.15	0.01	0.0034
	P	0.713	0.778	0.988	0.987
	N	15	27	15	26
HVLT-R	r	0.30	0.34	0.988	0.05
	P	0.566	0.433	0.776	0.971
	N	15	25	15	26
WMS III SS	r	0.47	0.10	−0.06	0.07
	P	0.320	0.798	0.988	0.971
	N	15	27	15	26
LNS	r	0.01	−0.17	0.04	−0.06
	P	0.977	0.751	0.776	0.971
	N	15	27	15	26
NAB-MAZES	r	0.33	0.03	0.18	−0.03
	P	0.566	0.987	0.988	0.971
	N	15	27	15	26
BVMT-R	r	0.47	0.29	−0.19	−0.07
	P	0.320	0.496	0.988	0.971
	N	15	27	15	26
Fluency	r	−0.15	0.	−0.36	0.13
	P	0.733	0.978	0.988	0.971
	N	15	27	15	26
MSCEIT ME	r	−0.26	0.25	0.23	−0.16
	P	0.583	0.729	0.988	0.971
	N	15	27	15	26
CPT-IT	r	0.11	0.29	0.05	−0.05
	P	0.783	0.164	0.988	0.971
	N	15	27	15	25

Data were generated from a total of 44 patients in the KaSP cohort with available data (median age = 24; interquartile range: 22–33; 16 females and 28 males). Number of included subjects are given in the table for each analysis. Correlations were performed using Spearman correlation analyses (two-sided P values corrected for multiple testing using Benjamini-Hochberg false discovery rate correction).

FEP-nSCZ first-episode patients that did not develop schizophrenia, FEP-SCZ first-episode patients that developed schizophrenia