Table 2.
Physical and sexual development at the initial visit in the ICPP and PT groups.
| Total | <7 years | ≥7 years | |||||||
|---|---|---|---|---|---|---|---|---|---|
| ICPP (n=142) |
PT (n=310) |
P value | ICPP (n=37) |
PT (n=152) |
P value | ICPP (n=105) |
PT (n=158) |
P value | |
| Chronological age (yr) | 7.1 ± 0.38 | 6.9 ± 0.29 | <0.01 | 6.8 ± 0.17 | 6.8 ± 0.27 | 0.721 | 7.2 ± 0.10 | 7.1 ± 0.11 | <0.01 |
| Height SDS | 1.30 ± 1.03 | 0.84 ± 0.87 | 0.010 | 1.46 ± 1.05 | 1.12 ± 0.85 | 0.239 | 1.31 ± 1.07 | 0.77 ± 0.88 | 0.011 |
| Height(cm) | 128.4 ± 5.70 | 125.3 ± 5.27 | <0.01 | 126.1 ± 4.86 | 124.8 ± 4.46 | 0.185 | 129.2 ± 5.44 | 125.7 ± 5.99 | <0.01 |
| Age of height equivalent in a normally developing girl (yr) (WHO) | 8.3 | 7.7 | 7.9 | 7.6 | 8.4 | 7.8 | |||
| Age of height equivalent in a normally developing girl (yr) (China) | 8 | 7.4 | 7.6 | 7.3 | 8.1 | 7.5 | |||
| Weight SDS | 1.67 ± 1.21 | 0.94 ± 0.99 | <0.01 | 2.07 ± 1.44 | 1.26 ± 1.13 | 0.056 | 1.46 ± 1.22 | 0.997 ± 1.15 | 0.275 |
| Weight (kg) | 27.9 ± 4.28 | 26.5 ± 3.21 | <0.01 | 28.3 ± 4.84 | 26.3 ± 3.59 | 0.047 | 27.8 ± 4.30 | 26.7 ± 4.90 | 0.096 |
| Age of weight equivalent in a normally developing girl (yr) (WHO) | 8.8 | 8.5 | 9.1 | 8.4 | 8.8 | 8.6 | |||
| Age of weight equivalent in a normally developing girl (yr) (China) | 8.8 | 8.5 | 9.1 | 8.4 | 8.8 | 8.6 | |||
| BMI SDS | 0.79 ± 0.95 | 0.04 ± 1.79 | 0.018 | 1.12 ± 1.14 | 0.39 ± 2.16 | 0.162 | 0.63 ± 0.91 | -0.16 ± 1.86 | 0.028 |
| BMI (kg/m2)) | 16.9 ± 1.80 | 16.0 ± 1.50 | <0.01 | 17.6 ± 2.07 | 16.0 ± 1.81 | 0.112 | 16.6 ± 2.0 | 16.0 ± 2.41 | 0.711 |
| Age of BMI equivalent in a normally developing girl (yr) (WHO) | 10.5 | 8.5 | 11.5 | 8.5 | 10 | 8.5 | |||
| Age of BMI equivalent in a normally developing girl (yr) (China) | 11.3 | 9.8 | 12.1 | 9.8 | 10.8 | 9.8 | |||
| BA (yr) | 9.2 ± 1.01 | 7.55 ± 1.16 | <0.01 | 8.31 ± 0.75 | 7.36 ± 1.05 | <0.01 | 9.33 ± 0.98 | 7.67 ± 1.20 | <0.01 |
| Basal LH (IU/L) | 0.48 ± 0.53 | 0.15 ± 0.15 | <0.01 | 0.50 ± 0.64 | 0.16 ± 0.16 | <0.01 | 0.47 ± 0.46 | 0.14 ± 0.14 | <0.01 |
| Basal FSH (IU/L) | 3.62 ± 2.24 | 2.35 ± 1.23 | <0.01 | 3.52 ± 1.80 | 2.29 ± 1.16 | <0.01 | 3.67 ± 2.45 | 2.48 ± 1.35 | <0.01 |
| E2 (pg/ml) | 33.5 ± 19.3 | 26.1 ± 15.8 | <0.01 | 31.5 ± 20.3 | 27.6 ± 16.1 | 0.208 | 34.6 ± 18.8 | 24.8 ± 15.6 | <0.01 |
| Uterine diameter (cm) | 3.85 ± 0.57 | 3.49 ± 0.52 | <0.01 | 3.71 ± 0.62 | 3.52 ± 0.49 | 0.079 | 3.92 ± 0.53 | 3.46 ± 0.56 | <0.01 |
| Ovarian volume (ml) | 1.64 ± 0.52 | 1.36 ± 0.46 | <0.01 | 1.55 ± 0.47 | 1.32 ± 0.46 | 0.022 | 1.68 ± 0.54 | 1.38 ± 0.46 | <0.01 |
| Number of follicles (>4mm) | 3.79 ± 2.11 | 2.93 ± 1.89 | <0.01 | 3.61 ± 1.62 | 3.23 ± 2.13 | 0.364 | 3.86 ± 2.28 | 2.63 ± 1.58 | <0.01 |
ICPP, idiopathic central precocious puberty; PT, premature thelarche; SDS, standard deviation score; BMI, body mass index; WHO, World Health Organization; BA, bone age; LH, luteinizing hormone; FSH, follicle stimulating hormone; E2, estrogen.