Skip to main content
. 2022 Nov 3;13:6585. doi: 10.1038/s41467-022-34225-5

Fig. 6. The FIB-1 RG/RGG domain shares partial genetic and functional redundancy with the NUCL-1 RG/RGG domain.

Fig. 6

a Deletion of FIB-1 RGG on NUCL-1 WT (left) and NUCL-1ΔRGG (right) backgrounds. Red X’s represent non-viability. b NUCL-1(FIB-1RGG)::sGFP11 protein. c NUCL-1(FIB-1RGG) localizes to germ cell nucleoli. d Pachytene germ cell nucleoli in NUCL-1 WT, NUCL-1ΔRGG, and NUCL-1(FIB-1RGG) worms. NUCL-1(FIB-1RGG) protein lacks compartmentalization into the GC and e only shows a slight improvement in CV compared to NUCL-1ΔRGG (n = 251 nucleoli from 13 NUCL-1 WT worms, 169 nucleoli from 9 NUCL-1ΔRGG worms, and 209 nucleoli from 12 NUCL-1(FIB-1RGG) worms). ****p < 0.0001; One-way ANOVA with Tukey’s multiple comparisons test. Points represent individual nucleoli and means ± SD are shown.