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. 2021 Jul 8;74(7):1174–1182. doi: 10.1093/cid/ciab613

Table 1.

Demographic Values and Rates for All Herpes Simplex Encephalitis (HSE) (Primary Diagnosis Only) Hospitalizations in the United States per Year

All Hospitalizationsa HSE Primary Diagnosis b Rate of HSE Cases per 100 000
Total n Weighted n % HSE n Weighted n %
95 068 178 207 468 667 100 4577 10 272 100 4.95
Gender
 Male 39374914 85 922 943 41.4 2230 5032 49.0 5.86
 Female 55 693 264 121 545 724 58.6 2347 5242 51.0 4.31
Age (continuous)
 Age, mean 56.0 59.9
Age (categorical)
 1–17 3 034 721 9 174 432 4.4 139 421 4.1 4.59
 18–44 26 462 071 57 808 211 27.9 736 1576 15.3 2.73
 45–64 26 777 643 57 777 828 27.8 1569 3598 35.0 6.23
 ≥65 38 793 743 82 708 199 39.9 2133 4677 45.5 5.65
Primary payorc
 Medicare/Medicaid 61 289 069 132 303 789 63.8 2741 6034 58.7 4.56
 Private 26 105 284 58 053 657 28.0 1453 3369 32.8 5.80
 Uninsured/other 76 58 215 17 081 738 8.2 383 871 8.5 5.10
Discharge dispositiond
 Home or self care 64 324 591 141 658 473 68.3 1572 3488 34.0 2.46
 Transfer, home health 27 215 115 58 469 192 28.2 2616 5883 57.3 10.06
 Against medical advice 1 318 245 2 652 412 1.3 45 85 0.8 3.20
 Other 40 752 74 241 0.0 4 7 0.1 9.43
 Death 2 120 875 4 513 341 2.2 337 804 7.8 17.81
Hospitalization
 Length of stay, mean 4.9 13.5

aHospitalizations and HSE cases exclude the last 60 days of each data set and are ≥1 year of age.

bHSE as primary diagnosis indicated by the first listed diagnosis, either “543” for International Classification Diagnosis Code, ninth edition or “B004,” “B100*” for the tenth edition. HSE cases in this table are not the same as index cases.

cPayor groups: Medicare/Medicaid = includes both fee-for-service and managed care patients; private = includes commercial carriers and private health maintenance organizations (HMOs)/preferred provider organizations (PPOs); uninsured/other = includes worker’s compensation, CHAMPUS, CHAMPVA, Title V, and other government programs.

dTransfer includes short-term hospitals, skilled nursing facility, or intermediate care facility.