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. 2022 Nov 4;12(11):149. doi: 10.1038/s41408-022-00745-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Unsupervised hierarchical clustering was performed using GATA-3 target genes identified in CTCL cell lines in a cohort of CTCL biopsy specimens, including those with and without large cell transformation (LCT), as indicated. Immunohistochemistry for GATA-3 was performed, and cases stratified by GATA-3 expression, as indicated. B Scatter plot showing GATA-3 target gene activity score for non-LCT (n = 31) and LCT (n = 34) CTCL specimens is shown. C GSEA analysis of CTCL cohorts for GATA-3 target genes in CTCL. D Unsupervised hierarchical clustering was performed using GATA-3 target genes identified in T-ALL cell lines in a cohort of T-ALL biopsy specimens, including those with and without early thymocyte progenitor (ETP), as indicated. Immunohistochemistry for GATA-3 was performed, and cased stratified by GATA-3 expression, as indicated. E Scatter plot showing GATA-3 target gene activity score for non-ETP (n = 16) and ETP (n = 9) T-ALL specimens is shown. F GSEA analysis of T-ALL cohorts for GATA-3 target genes in T-ALL. G Venn diagram showing overlapping target genes between CTCL and T-ALL. Target genes identified in two out of three CTCL cell lines and in two out of four T-ALL cell lines were included for analysis. GATA-3 target genes of therapeutic interest are highlighted in red. Data are represented as mean ± s.e.m. (standard error of the mean). **p < 0.01.