Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), formerly also called baboon syndrome, is characterized by symmetrical erythematous rash with typical localization in the gluteal and intertriginous areas.

CGRP monoclonal antibodies (CGRP mAbs) are a new class of drugs for the prevention of migraine.

We present the first case of SDRIFE occurring in temporal relation to the use of erenumab for migraine prevention.

In view of the widespread nature of migraine, knowledge of this unusual dermatological rare syndrome is important.

It is crucial to recognize the relationship between the medication and the circumscribed exanthema occurring distant from the injection site.