Table 1.
Characteristics of the cohort under study by age classes.
| Age classes | P value | ||||||
|---|---|---|---|---|---|---|---|
| <65 years (n = 615) | 65–69 years (n = 242) | 70–74 years (n = 200) | 75–79 years (n = 193) | 80–84 years (n = 156) | 85–89 years (n = 76) | ||
| Gender, female | 279 (45.4%) | 87 (36.0%) | 69 (34.5%) | 87 (45.1%) | 75 (48.1%) | 47 (61.8%) | < 0.001 |
| Comorbidities, yes | 287 (46.7%) | 158 (65.3%) | 140 (7.0%) | 146 (75.6%) | 138 (88.5%) | 59 (77.6%) | < 0.001 |
| CACI, median (IQR) | 4 (3-5) | 5 (4-6) | 6 (5-7) | 6 (5-7) | 7 (6-8) | 7 (6-8) | < 0.001 |
| CACI ≥5 | 160 (25.8%) | 109 (45%) | 172 (86%) | 166 (86.1%) | 152 (96.8%) | 65 (85.5%) | < 0.001 |
| BMI, median (IQR) | 24.8 (22.5-27.9) | 25.5 (23.4-27.5) | 25.6 (23.8-27.9) | 24.9 (22.5-28.0) | 26.1 (23.3-28.3) | 24.2 (21.6-27.5) | 0. 23 |
| Elective surgery | 593 (96.4%) | 231 (95.5%) | 194 (97.0%) | 179 (92.8%) | 143 (91.7%) | 65 (85.5%) | < 0.001 |
| Laparoscopic surgery | 206 (33.5%) | 83 (34.3%) | 51 (25.5%) | 47 (24.4%) | 34 (21.8%) | 22 (29.0%) | 0.008 |
| Postoperative mortality | 0 (0.0%) | 2 (0.8%) | 0 (0.0%) | 2 (1.0%) | 5 (3.2%) | 3 (4.0%) | < 0.001 |
| Postoperative complications | 139 (22.6%) | 61 (25.2%) | 53 (26.5%) | 60 (31.1%) | 54 (34.6%) | 24 (31.6%) | 0.008 |
| Neoadjuvant therapy, yes* | 129 (23.8%) | 34 (16.0%) | 18 (10.0%) | 19 (11.2%) | 11 (7.9%) | 0 (0.0%) | < 0.001 |
|
Neoadjuvant type
CHT CRT RT |
53 (41.1%) 73 (56.6%) 3 (2.3%) |
15 (44.1%) 17 (50.0%) 2 (5.9%) |
9 (50.0%) 9 (50.0%) 0 (0.0%) |
5 (26.3%) 13 (68.4%) 1 (5.3%) |
1 (9.1%) 6 (54.5%) 4 (36.4%) |
- - - |
0.009 |
|
Tumour location
Left colon Right colon Rectum |
256 (41.6%) 165 (26.8%) 199 (32.3%) |
95 (39.2%) 84 (34.7%) 63 (26.0%) |
91 (45.5%) 66 (33.0%) 43 (21.5%) |
68 (35.2%) 74 (38.3%) 51 (26.4%) |
54 (34.6%) 64 (41.0%) 39 (25.0%) |
27 (35.5%) 41 (53.9%) 8 (10.5%) |
< 0.001 |
|
Stage
0–I II III IV |
197 (31.8%) 127 (20.5%) 151 (24.4%) 144 (23.3%) |
84(34.7%) 62 (25.6%) 50 (20.7%) 46 (19%) |
50 (25%) 64 (32%) 55 (27.5%) 31 (15.5%) |
50 (26%) 67 (35%) 43 (22.4%) 32 (16.6%) |
34 (21.8%) 55 (35.2%) 42 (27%) 25 (16%) |
11 (14.5%) 29 (38.2%) 21 (27.6%) 13 (17.1%) |
< 0.001 |
| Potentially curative (R0–1) | 539 (87.6%) | 219 (90.5%) | 176 (88%) | 170 (88.1%) | 140 (89.7%) | 63 (82.9%) | 0.540 |
| Adjuvant therapy, yes° | 93 (20.2%) | 27 (14.5%) | 21 (13.5%) | 9 (6.0%) | 6 (5.1%) | 2 (3.8%) | < 0.001 |
| Number of retrieved lymph-nodes ≥12 | 526 (87.1%) | 204 (85.7%) | 158 (81.0%) | 148 (79.1%) | 125 (81.2%) | 54 (77.1%) | 0.027 |
Data are expressed as number of patients (%) or median (IQR).
CACI (Charlson-Age Comorbidity Index); BMI (body max index).
*Information available for 1,317/1,482 patients.
°Information available for 1,121/1,482 patients.
p values – 0.05 were highlighted in bold.