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. 2022 Oct 27;11(4):316–330. doi: 10.7762/cnr.2022.11.4.316

Figure 1. Regulation of HAMP expression in the cell. BMP/SMAD and JAK2/STAT3 signaling pathways regulate the expression of HAMP.

Figure 1

HAMP, hepcidin; BMP, bone morphogenetic protein; BMPR, bone morphogenetic protein receptor; SMAD, small-mothers-against-decapentaplegic protein; JAK2, Janus kinase 2; STAT3, signal transducer and activator of transcription 3; HFE, homeostatic iron regulator; HJV, hemojuvelin; holo-Tf, diferric-transferrin; IL-6, interleukin-6; IL-6R, interleukin-6 receptor; TfR, transferrin receptor.