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. 2022 Oct 21;10:1001396. doi: 10.3389/fbioe.2022.1001396

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Copyright © 2022 Gu, Gao, Zafar, Chu, Feng, Ni, Xu and Bao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) and (B) The BBB scores and inclined plate angles of SCI for 8 weeks. The results of the SHH-RMSC group were significantly higher than those of the model, sham, and RMSC, and the difference was statistically significant (**, p < 0.01, compared with model; ^##, p < 0.01, compared with MSCs; Δ, p < 0.01, compared with sham). (C) H&E staining of SCI. SHH-RMSCs group improved significantly, while the tissue arrangement tended to be normal, and the extracellular space was significantly reduced.