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. 2022 Oct 21;13:1016263. doi: 10.3389/fimmu.2022.1016263

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Copyright © 2022 Nicolò, Amendt, El Ayoubi, Young, Finzel, Senel, Voll and Jumaa

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RF^low prevails over RF^high. Blood glucose concentrations of WT mice intravenously (i.v.) injected with 100 µg α-insulin IgG in combination with 20 µg RF^high (green bar, n = 7), 20 µg RF^low (purple bar, n = 6), 20 µg RF^{low +} 20 µg RF^high (orange bar, n = 7) or mIgM control (blue bar, n = 5) measured at indicated time points. Mean ± SD, statistical significance was calculated using two-way ANOVA with Tukey’s multiple comparisons test. *p < 0,05; **p < 0,01; ***p < 0,001; ****p < 0,0001.