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. 2022 Sep 21;22(5):e37. doi: 10.4110/in.2022.22.e37

Table 1. Clinical trials using CAR or CAAR T cells in autoimmune diseases.

NCT number Title Status Conditions Interventions Study start Study completion Study report Phase
NCT03030976 A Study of CD19 Redirected Autologous T Cells for CD19 Positive Systemic Lupus Erythematosus (SLE) Unknown SLE CD19 CAR T-cells Mar-17 Mar-18 No results posted I
NCT05030779 A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Systemic Lupus Erythematosus Recruiting SLE CD19/BCMA CAR T-cells Sep-21 Sep-22 Active I
NCT05085418 A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Immune Nephritis Recruiting Immune Nephritis CD19/BCMA CAR T-cells Nov-21 Nov-24 Active I
NCT04422912 Open-label Study to Determine the Maximum Tolerated Dose of DSG3-CAART in Mucosal-dominant PV Patients (mPV) Recruiting mPV DSG3-CAART Sep-20 Sep-26 Active I
NCT05085431 A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Sjogren's Syndrome Recruiting Syndrome CD19/BCMA CAR T-cells Nov-21 Nov-24 Active I
NCT05085444 A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Scleroderma Recruiting Scleroderma CD19/BCMA CAR T-cells Oct-21 Oct-24 Active I
NCT04561557 Safety and Efficacy of CT103A Cells for Relapsed/Refractory Antibody-associated Idiopathic Inflammatory Diseases of the Nervous System Recruiting Neuromyelitis Optica Spectrum Disorder BCMA CAR T-cells (CT103A) Sep-20 Dec-23 Active I
NCT04146051 Descartes-08 CAR-T Cells in Generalized Myasthenia Gravis (MG) Recruiting Generalized MG BCMA CAR T-cells (Descartes-08) Dec-19 Dec-23 Active I/II
NCT05263817 A Clinical Study of CD19/BCMA CAR-T Cells in the Treatment of Refractory POEMS Syndrome, Amyloidosis, Autoimmune Hemolytic Anemia, and Vasculitis Recruiting Refractory POEMS Syndrome, Amyloidosis, Autoimmune Hemolytic Anemia, and Vasculitis CD19/BCMA CAR T cells Oct-21 Oct-24 Active I
NCT05239702 Clinical Study of Targeting CD7 CAR-T Cells in the Treatment of Autoimmune Diseases Recruiting Crohn’s Disease, Ulcerative Colitis, Dermatomyositis, Still's Disease, Autoimmune Diseases CD7 CAR T cells Feb-22 Dec-24 Active I
NCT05451212 Open-label Study to Determine the Maximum Tolerated Dose of MuSK-CAART for MuSK Myasthenia Gravis Not yet recruiting MuSK MG MuSK-CAART Oct-22 Oct-28 Active I