Table 3.
Univariate and multivariable analysis of overall survival (OS) predictors in breast cancer patients after PSM.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Variables | HR* | 95%CI | P-value | HR* | 95%CI | P-value |
| Age | 0.984 | (0.967, 1.001) | 0.058 | 0.986 | (0.969, 1.003) | 0.111 |
| Race | ||||||
| Black | Reference | Reference | ||||
| Other | 0.593 | (0.486, 0.723) | 0.000 | 0.720 | (0.589, 0.881) | 0.001 |
| White | 0.624 | (0.548, 0.711) | 0.000 | 0.693 | (0.605, 0.792) | 0.000 |
| Laterality | ||||||
| Left | Reference | |||||
| Right | 1.031 | (0.927, 1.146) | 0.575 | |||
| Marital | ||||||
| No | Reference | Reference | ||||
| Yes | 0.876 | (0.787, 0.976) | 0.016 | 0.931 | (0.832, 1.042) | 0.215 |
| Grade | ||||||
| I | Reference | Reference | ||||
| II | 2.351 | (1.617, 3.417) | 0.000 | 1.958 | (1.345, 2.851) | 0.000 |
| III | 3.373 | (2.346, 4.851) | 0.000 | 2.472 | (1.711, 3.570) | 0.000 |
| IV | 3.110 | (1.903, 5.082) | 0.000 | 2.546 | (1.554, 4.171) | 0.000 |
| Histology | ||||||
| IDC | Reference | |||||
| ILC | 1.036 | (0.659, 1.63) | 0.879 | |||
| Other | 0.775 | (0.633, 0.95) | 0.014 | |||
| T stage | ||||||
| T1 | Reference | Reference | ||||
| T2 | 1.635 | (1.458, 1.834) | 0.000 | 1.294 | (1.149, 1.458) | 0.000 |
| T3 | 2.339 | (1.925, 2.843) | 0.000 | 1.761 | (1.441, 2.154) | 0.000 |
| N stage | ||||||
| N0 | Reference | Reference | ||||
| N1 | 1.727 | (1.519, 1.962) | 0.000 | 1.701 | (1.485, 1.948) | 0.000 |
| N2 | 2.750 | (2.339, 3.233) | 0.000 | 2.564 | (2.157, 3.049) | 0.000 |
| N3 | 4.905 | (4.073, 5.908) | 0.000 | 4.342 | (3.566, 5.287) | 0.000 |
| Chemotherapy | ||||||
| No | Reference | Reference | ||||
| Yes | 1.392 | (1.197, 1.619) | 0.000 | 0.955 | (0.809, 1.127) | 0.584 |
| Radiation | ||||||
| No | Reference | Reference | ||||
| Yes | 1.380 | (1.236, 1.54) | 0.000 | 0.978 | (0.862, 1.110) | 0.728 |
| Surgery | ||||||
| BCS | Reference | Reference | ||||
| Mastectomy | 1.138 | (1.023, 1.265) | 0.018 | 1.127 | (1.013, 1.254) | 0.028 |
| Subtype | ||||||
| HR-/HER2- | Reference | Reference | ||||
| HR-/HER2+ | 0.524 | (0.285, 0.964) | 0.038 | 0.545 | (0.296, 1.003) | 0.051 |
| HR+/HER2- | 0.418 | (0.305, 0.574) | 0.000 | 0.475 | (0.345, 0.654) | 0.000 |
| HR+/HER2+ | 0.279 | (0.169, 0.461) | 0.000 | 0.301 | (0.182, 0.498) | 0.000 |
| Not 2010+ | 0.69 | (0.544, 0.874) | 0.002 | 0.704 | (0.553, 0.897) | 0.004 |
BCS, Breast conserving surgery; IDC, Invasive ductal carcinoma; ILC, Invasive lobular carcinoma; HR, Hormone receptor; HER2, Human epidermal growth factor receptor 2; HR*, hazard ratio; CI, confidence interval.