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. 2022 Oct 24;24(6):728. doi: 10.3892/etm.2022.11664

Figure 3.

Figure 3

Effects of bevacizumab on the protein expression levels of VEGF, MMP-9, occludin and collagen-IV, brain edema and neurological score at 24 h post-TBI. Protein expression levels of (A) VEGF, (B) MMP-9, (C) occludin and (D) collagen-IV, and (E) brain water content and (F) neurological scores were assessed to determine the effects of bevacizumab at 24 h post-TBI. Protein levels were normalized to levels in the Sham group. Statistical analyses of western blotting and brain edema were performed using one-way ANOVA with Tukey's test post hoc. Statistical analyses of neurological scores were performed using Kruskal-Wallis test with post hoc Dunn's test. n=6/group. ***P<0.001 vs. Sham group; &&P<0.01, &&&P<0.001 vs. TBI + Vehicle group. TBI, traumatic brain injury; TBI + Beva, TBI + bevacizumab.