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. 2022 Oct 24;24(6):728. doi: 10.3892/etm.2022.11664

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Copyright: © Wu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of bevacizumab on neuronal apoptosis and necrosis 24 h after TBI. (A) Representative TUNEL assay images showing TUNEL-positive (green) apoptotic cells and DAPI-stained (blue) nuclei. (B) Representative FJC staining assay images showing cell necrosis. (C) Apoptotic and (D) necrotic cells. Scale bar, 50 µm. One-way ANOVA with Tukey's post hoc test was utilized for group comparisons n=6/group. ^***P<0.001 vs. Sham group; ^&&P<0.01, ^&&&P<0.001 vs. TBI + Vehicle group. TBI, traumatic brain injury; TBI + Beva, TBI + bevacizumab; FJC, Fluoro-Jade C.