Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic diagram of the possible mechanism by which VEGF affects secondary brain injury post-traumatic brain injury via MMP-9. After TBI, VEGF and MMP-9 levels in the brain tissue surrounding the injured area were increased. By decreasing occludin and collagen-IV levels, blood-brain barrier permeability may be enhanced, leading to an increase in water content, and further resulting in apoptosis and necrosis. Inhibition of VEGF by bevacizumab may reverse this damage.
