TABLE 3.
Total (nonspecific) immunoglobulin isotype and subclass leels
| Isotype | Median concna (interquartile range)
|
Kruskal-Wallis P value | ||
|---|---|---|---|---|
| Category 1 | Category 2 | Category 3 | ||
| IgE | 1,239 (525–1,800) | 1,036 (544–1,892) | 681 (456–1,237) | 0.06 |
| IgG | 21.4 (19.0–22.1) | 22.1 (18.4–24.6) | 23.9 (20.5–25.4) | 0.09 |
| IgM | 1.57 (0.92–3.31) | 1.57 (1.15–2.54) | 2.38 (1.55–2.92) | NSb |
| IgA | 1.66 (1.22–2.42) | 1.55 (1.16–2.03) | 1.72 (1.21–2.06) | NS |
| IgG1 | 18.0 (14.6–19.7) | 19.6 (17.0–25.0) | 19.1 (16.4–22.9) | NS |
| IgG2 | 1.73 (1.12–2.46) | 1.81 (1.47–2.66) | 1.63 (0.84–2.50) | NS |
| IgG3 | 2.06 (1.0–3.41) | 2.36 (1.46–4.41) | 3.65 (1.63–6.48) | NS |
| IgG4 | 0.47 (0.20–0.80) | 0.25 (0.12–0.75) | 0.28 (0.17–0.45) | NS |
a
Measured as described in Materials and Methods. Concentrations are expressed in IU (IgE) or milligrams (other isotypes) per milliliter. For comparison, the normal ranges found for healthy unselected Europeans 5 to 15 years old are as follows: IgG, 5.4 to 16.1; IgM, 0.5 to 1.9; IgA, 0.5 to 2.8; IgG1, 3.6 to 7.7; IgG2, 1.4 to 4.6; IgG3, 0.3 to 1.2; and IgG4, <1.3 (47). Total IgG correlated with the sum of the individual IgG subclasses (Spearman’s rho, r = 0.64, P < 0.001. Significantly higher levels of IgG and IgG3 and significantly lower levels of IgE occurred in category 3 subjects compared with those in category 1 (P = 0.02, 0.04, and 0.05, respectively).
b
NS, not significant.