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. 2022 Oct 21;16:1009125. doi: 10.3389/fnins.2022.1009125

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Copyright © 2022 Angelopoulos, Gakis, Birmpas, Kyrousi, Habeos, Kaplani, Lygerou, Habeos and Taraviras.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TCA cycle metabolites and stem cell fate. The interplay between the metabolic mitochondrial and epigenetic factors regulating neural stem cell fate decisions. 1CM, 1-carbon cycle; Ac, acetyl group; Ac-CoA, Acetyl-CoA; a-KG, Alpha-ketoglutarate; ACLY, ATP citrate lyase; DNMT, DNA methyl transferase; ETC, electron transport chain; HAT, histone acetyl transferase; JHDM, JmjC domain-containing histone demethylation protein; KMT, histone lysine N-methyltransferase; L-2-HG, L-2-hydroxyglutarate; LDH, lactate dehydrogenase; MDH1, malate dehydrogenase 1; MDH2, malate dehydrogenase 2; Me, Methyl group; MPC, mitochondrial pyruvate carrier; NAD, Nicotinamide adenine dinucleotide; OAA, oxaloacetate; PDH, pyruvate dehydrogenase; SAM, S-Adenosyl methionine; TDH, threonine dehydrogenase; TET, Ten Eleven Translocation enzyme.