Table 1:
1. | Histologic/cytologic documentation of stage IV NSCLC or stage III in patients who are not candidates for standard chemo-radiotherapy |
2. | PD-L1 Tumor Proportion Score (TPS) TPS < 1% based on local testing |
3. | EGFR, ALK and ROS1 (−)* based on local testing |
4. | Measurable disease with at least one lesion amenable to SBRT |
5. | ECOG Performance Status 0-2 |
6. | No Prior Treatment for this malignancy |
7. | No comorbid conditions that would preclude immunotherapy |
8. | Age ≥18 years |
9. | No active other malignancies |
10. | No live vaccines within 30 days |
11. | Organ function criteria: |
Absolute neutrophil count ≥1500/mm3 | |
Platelet count ≥100,000 | |
Creatinine Clearance ≥45 mL/minute | |
Total Bilirubin ≤1.5 x Normal | |
AST/ALT ≤2.5 x Normal | |
12. | Treated or small asymptomatic brain metastasis patients are eligible |
epidermal growth factor receptor, anaplastic lymphoma kinase