Table 2.

Nox Isoform Involvement in Peripheral Nervous System Disorders

PNS disorder	Nox isoform(s) involved	Potential role(s)	References
Neuropathic pain	(a) Nox1 (b) Nox2 (c) Nox4	(a) Macrophage infiltration; thermal and mechanical hyperalgesia (b) Central and peripheral immune regulation in pain sensitization after peripheral nerve injury (c) Peripheral pain processing, neuroinflammation, and dysmyelination	(28, 42, 59, 70, 72)
CIDP	Nox2	Unclear	(91)
CIPN	Nox4	Pain hypersensitivity; increased proinflammatory mediators	(96, 97)
DPN	(a) Nox2 (b) Nox4	(a) Pain processing and allodynia (b) Schwann cell injury; neurophysiological defects	(21, 35, 136)

CIDP, chronic inflammatory demyelinating polyneuropathy; CIPN, chemotherapy-induced peripheral neuropathy; DPN, diabetic peripheral neuropathy.