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. Author manuscript; available in PMC: 2022 Nov 4.
Published in final edited form as: Nature. 2022 Feb 14;603(7903):885–892. doi: 10.1038/s41586-021-04369-3

Extended Data Fig. 4. Human brain vascular expression of genes relevant to disease.

Extended Data Fig. 4.

a, Brain vascular expression of genes relevant to SARS-CoV-2 brain entry, as summarized in Iadecola, et al. 202078.

b, Expression of the mouse perivascular fibroblast-like gene Spp1 is instead specifically expressed in human myeloid cells and oligodendrocytes (SPP1, top)79.

c, No expression of the immuno-oncology target CD19 and its chaperone CD81 across human adult brain pericytes and smooth muscle cells80. Note: cells with any finite expression are ordered to the front to ensure all expression is visible, but this carries the potential to visually overestimate average expression