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. 2022 Nov 4;19:267. doi: 10.1186/s12974-022-02629-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Trem2 expression is prominently increased in SC infiltrating BMDM during MHV–JHM CNS infection. A Trem2 and Tyrobp mRNA expression in brains and SCs from 5–6 mice at days 0, 5, 7, 10 and 14 pi after intracranial MHV–JHM infection. Data show the mean ± SEM from 2 independent experiments (n = 3–4 mice/timepoint/experiment) and are analyzed by unpaired two-tailed Student t test and two-way ANOVA analysis followed by Bonferroni test. ****p < 0.00001. B Normalized Trem2 and Tyrobp mRNA expression from Nanostring nCounter analysis of microglia and BMDM sorted from pooled SC of 5–7 mice at days 0, 5, 7, 10 and 14 pi from our previously published data (GSE214472) [22]