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. 2022 Nov 4;24:249. doi: 10.1186/s13075-022-02938-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — BD serum promotes M1-like macrophage polarization. Resting macrophages (M0) were stimulated with M1 condition (100ng/ml LPS+ 20ng/ml IFNγ), M2 condition (20ng/ml IL-4+ 20ng/ml IL-13), BD serum or HC serum for 48 h. A–C Representative histograms (left) and summary (right) of CD86, CD163 and CD206 expression level of macrophages stimulated with M0 (n=6), M1 (n=6), and M2 (n=6) conditions, as well as BD (n=12) serum and HC (n=12) serum. Data were expressed as mean±SD and were analyzed using one-way ANOVA. D IL-12 and TNF-α production by macrophages stimulated with M0 (n=6), M1 (n=6), and M2 (n=6) conditions, as well as BD (n=12) serum and HC (n=12) serum. Data were expressed as mean±SD and were analyzed using Kruskal-Wallis test. E Representative histograms (left) and summary (right) of dextran uptake by macrophages stimulated with M0 (n=7), M1 (n=7), M2 (n=7) conditions, and BD (n=9) serum and HC (n=9) serum. Data were expressed as mean±SD and were analyzed using one-way ANOVA. *, p<0.05; **, p<0.01; ***, p<0.001, ****, p<0.001. M_BD, BD serum-treated macrophages; M_HC, HC serum-treated macrophages