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. 2022 Nov 3;22:334. doi: 10.1186/s12935-022-02737-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — A Hierarchical clustering of the samples based on the top-ranked DMPs (n = 156): Illustrative heat map denoting the Hierarchical Clustering of the PDAC samples (n = 7) based on the top-ranked DMPs (n = 156). Blue to red denoted increase in beta value (hyper-methylation). The cancer samples were marked as Blue and the normal samples were marked as Black (B) Genomic annotations of DMPs-CpG islands (Islands, Shores (± 2 KB from the boundaries of the islands), Shelves (± 2 KB from the boundaries of the shores) and Open Sea) or the transcription start site (5ʹ UTR, Exon 1, Promoter, Body, Non-genic). Distribution of the hypo-methylated and hyper-methylated DMPs across different segments of the genome. C Venn diagram showing common and uncommon DMPs in the TCGA cohort and Indian cohort. Among the 7832 DMPs, 68 DMPs were common to our study finding. D Correlation plot between the delta beta values at these 68 DMPs in TCGA data (for 9 PAAD patients) and in Indian cohort (n = 7)